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Identification of alternative transcripts of rat CD9 expressed by tumorigenic neural cell lines and in normal tissues Genet. Mol. Biol.
Wolfahrt,Sonja; Herman,Sandra; Scholz,Claus-Jürgen; Sauer,Georg; Deissler,Helmut.
CD9 is the best-studied member of the tetraspanin family of transmembrane proteins. It is involved in various fundamental cellular processes and its altered expression is a characteristic of malignant cells of different origins. Despite numerous investigations confirming its fundamental role, the heterogeneity of CD9 or other tetraspanin proteins was considered only to be caused by posttranslational modification, rather than alternative splicing. Here we describe the first identification of CD9 transcript variants expressed by cell lines derived from fetal rat brain cells. Variant mRNA-B lacks a potential translation initiation codon in the alternative exon 1 and seems to be characteristic of the tumorigenic BT cell lines. In contrast, variant mRNA-C can...
Tipo: Info:eu-repo/semantics/article Palavras-chave: CD9; Tetraspanin; Transcript; Splice variant; Membrane topology.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000200019
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Salt Shock Responses of Microcystis Revealed through Physiological, Transcript, and Metabolomic Analyses ArchiMer
Georges Des Aulnois, Maxime; Réveillon, Damien; Robert, Elise; Caruana, Amandine; Briand, Enora; Guljamow, Arthur; Dittmann, Elke; Amzil, Zouher; Bormans, Myriam.
The transfer of Microcystis aeruginosa from freshwater to estuaries has been described worldwide and salinity is reported as the main factor controlling the expansion of M. aeruginosa to coastal environments. Analyzing the expression levels of targeted genes and employing both targeted and non-targeted metabolomic approaches, this study investigated the e ect of a sudden salt increase on the physiological and metabolic responses of two toxic M. aeruginosa strains separately isolated from fresh and brackish waters, respectively, PCC 7820 and 7806. Supported by di erences in gene expressions and metabolic profiles, salt tolerance was found to be strain specific. An increase in salinity decreased the growth of M. aeruginosa with a lesser impact on the...
Tipo: Text Palavras-chave: Microcystis aeruginosa; Microcystin; Salt stress; Metabolomic; Transcript.
Ano: 2020 URL: https://archimer.ifremer.fr/doc/00615/72689/71692.pdf
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